Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS CoV-2), which has caused the Covid-19 pandemic has created
panic in everyone’s mind, it is therefore necessary to predict protection
against SARS-CoV-2, and understand the quantity, quality, and duration of the
antibody response during different stages of Covid-19 and in the convalescent
period.
SARS CoV-2 Neutralizing Antibody
test
Quantitative FDA approved Test to
detect circulating neutralizing Antibodies against SARS CoV that neutralize RBD-ACE
interaction. In this regard, assessing the level of neutralizing antibodies
(NAbs) that block viral entry into cells could be a critical parameter in
determining protection from SARS-CoV-2 and management of convalescent plasma
therapies.
Who should be tested for SARS CoV-
2 Neutralizing Antibody test?
Patients with high spike Antibody titre
post vaccinated to check
neutralizing Antibodies.
Frequent Travelers- high
neutralizing Ab confirms
better immunity to fight
SARS CoV-2
Deciding plasma therapy
Specimen Type: Serum/Plasma
Advantages of SARS CoV-2 Neutralizing
Antibody test
Individual Comprehensive Antibody
panels for detection of Spike Antibody & Neutralizing Antibody
Quantitative results
Better sensitivity & specificity
Faster reporting in current
scenario
Interpretive reporting for
determining seroconversion, plasma therapy & accessing vaccine candidates
References-
a) SARS-CoV-2 specific antibody
and neutralization assays reveal the wide range of the humoral immune response
to virus | Communications Biology (nature.com)
b) Hoffmann, M. et al. SARS-CoV-2 cell entry
depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease
inhibitor. Cell 181, 271–280.e278 (2020).